Journal of Pathology and Translational Medicine

Original Article

Clinical and Prognostic Significances of Cytokeratin 19 and KIT Expression in Surgically Resectable Pancreatic Neuroendocrine Tumors: Eun-Mi Son, Joo Young Kim, Soyeon An, Ki-Byung Song, Song Cheol Kim, Eunsil Yu, Seung-Mo Hong; J Pathol Transl Med. 2015;49(1):30-36. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.10.23

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Background
Pancreatic neuroendocrine tumors (PanNETs) are malignant endocrine neoplasms that present diverse clinical behaviors. Therefore, identification of biomarkers of PanNETs is important for stratification of the prognosis of PanNET patients. Recently, cytokeratin 19 (CK19) and KIT expression were reported to have prognostic significance in PanNET patients. Methods: To identify their prognostic significance, CK19 and KIT protein expression were assessed in 182 surgically resected PanNETs and compared with clinicopathologic factors. Results: Of 182 PanNETs cases, CK19 and KIT expression was noted in 97 (53.3%) and 16 (8.8%) cases, respectively. PanNET patients with CK19 expression had larger tumors (p=.006), higher World Health Organization (WHO) grade (p=.002) and pT classification (p<.001), increased distant metastasis (p=.004), and lymphovascular (p=.012) and perineural (p=.019) invasion. Similarly, those with KIT expression had larger tumors (p=.030), higher WHO grade (p=.001), advanced pT classification (p<.001), distant metastasis (p=.001), and lymphovascular invasion (p=.014). The 5-year survival rate for PanNET patients with KIT expression was significantly lower (62%) than that of patients without KIT expression (77%, p=.011), as determined by univariate but not by multivariate analyses. Conclusions: CK19 and KIT expression correlate with higher metastatic potential and advanced disease stage, and KIT expression is associated with worse survival in PanNET patients.

Citations

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Brief Case Report

Mixed Carcinoid-Mucinous Adenocarcinoma Arising in Mature Teratoma of Mesentery: Su-Jin Shin, Eun-Mi Son, Chang Ohk Sung, Kyu-Rae Kim; J Pathol Transl Med. 2015;49(1):61-65. Published online January 15, 2015; DOI: https://doi.org/10.4132/jptm.2014.09.17

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Citations to this article as recorded by

Mixed neuroendocrine/Non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma
Sandhyarani Dasaraju, Khalid Amin, Molly E. Klein, Colleen Rivard, Jordan Mattson, Sarah Davidson, Mahmoud A. Khalifa
Gynecologic Oncology Reports.2022; 44: 101099. CrossRef
A Case of Mature Cystic Teratoma of the Mesentery
Ryogo Ito, Motoi Yoshihara, Atsuki Arimoto, Taro Aoba, Yoshihisa Shibata, Kazuhiro Hiramatsu, Takehito Kato
The Japanese Journal of Gastroenterological Surgery.2021; 54(5): 344. CrossRef
Primary ovarian mixed strumal and mucinous carcinoid arising in an ovarian mature cystic teratoma
Na Rae Kim, Seung Yeon Ha, Jin Woo Shin, Soyi Lim, Chan Yong Park, Hyun Yee Cho
Journal of Obstetrics and Gynaecology Research.2016; 42(2): 211. CrossRef

Original Article

Primary Squamous Cell Carcinoma of the Upper Genital Tract: Utility of p16^INK4a Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical Squamous Cell Carcinoma: Su Hyun Yoo, Eun-Mi Son, Chang Okh Sung, Kyu-Rae Kim; Korean J Pathol. 2013;47(6):549-556. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.549

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Abstract PDF

Background

Primary squamous cell carcinoma (SCC) of the upper genital tract, including the endometrium, fallopian tubes, and ovaries, is extremely rare. It must be distinguished from the mucosal extension of primary cervical SCC because determination of the primary tumor site is important for tumor staging. However, patients with SCC of the fallopian tubes or ovarian surface have often undergone prior hysterectomy with inadequate examination of the cervix, making it difficult to determine the primary site.

Methods

We compared histologic findings, p16^INK4a expression, and human papillomavirus (HPV) DNA status in four patients with primary SCC of the upper genital tract and five patients with primary cervical SCC extending to the mucosa of the upper genital tract.

Results

All five SCCs of cervical origin showed strong expression of p16^INK4a, whereas all four SCCs of the upper genital tract were negative, although one showed weak focal staining. Three of the five cervical SCCs were positive for HPV16 DNA, whereas all four primary SCCs of the upper genital tract were negative for HPV DNA.

Conclusions

Although a thorough histological examination is important, immunonegativity for p16^INK4a and negative for HPV DNA may be useful adjuncts in determining primary SCCs of the upper genital tract.

Citations

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Molecular Analysis of HPV-independent Primary Endometrial Squamous Cell Carcinoma Reveals TP53 and CDKN2A Comutations
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American Journal of Surgical Pathology.2022; 46(12): 1611. CrossRef
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Überraschung in der Abradatdiagnostik
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Annals of Surgical Oncology.2015; 22(9): 3049. CrossRef

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